Research Highlights

Our research centers on deciphering the cellular and molecular mechanisms controlling antitumor immunity, and exploiting knowledge to device the next-generation cancer immunotherapies.

Two active research projects are:

  1. Identify new immune checkpoints and develop new immune checkpoint blockade therapy for cancer.
  2. Develop stem cell-engineered, “off-the-shelf” CAR-iNKT cell therapy for treating a broad range of blood cancers and solid tumors. 

Featured Publications

Li Y-R*, Zhou Y*, Kim Y, Zhu Y, Ma F, Yu J, Wang Y-C, Chen X, Li Z, Zeng S, Wang X, Lee D, Ku J, Tsao T, Hardoy C, Huang J, Cheng D, Montel-Hagen A, Seet CS, Crooks GM, Larson SM, Sasine JP, Wang X, Pellegrini M, Ribas A, Kohn DB, Witte O, Wang P, and Yang L. (Co-first authors). Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy. Cell Rep. Med. 2021 (epub on November 16) [Cell Reports Medicine  PDF][UCLA News  PDF][BSCRC News  PDF][JCCC News  PDF][Life Sciences News  PDF][Science Daily  PDF][CIRM Blog  PDF]

Wang Y-C, Wang X, Yu J, Ma F, Li Z, Zhou Y, Zeng S, Ma X, Li Y-R, Neal A, Huang J, To A, Clarke N, Memarzadeh S, Pellegrini M, and Yang L. Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy. Nat. Commun. 2021, 12:3530 (epub on June 10) [Nature Communications  PDF][UCLA News  PDF][CBS News  PDF][NBC News  PDF][Fierce Biotech News  PDF][Drug Target Review News  PDF]

Wang X, Li B, Kim Y, Wang Y, Li Z, Yu J, Zeng S, Ma X, Choi I, Di Biase S, Smith DJ, Zhou Y, Li Y, Ma F, Huang J, Clarke N, To A, Gong L, Pham A, Moon H, Pellegrini M, and Yang L. Targeting monoamine oxidase A for T cell-based cancer immunotherapy. Sci. Immunol. 2021, 6:eabh2383 (epub ahead of print). [Science Immunology  PDF][Science Magazine News  PDF][UCLA News  PDF][CBS News  PDF][NBC News  PDF][Fierce Biotech News  PDF][Drug Target Review News  PDF]

Featured News

November 22, 2021

We are currently recruiting PhD students (2 openings) and postdoctoral researchers (2 openings). Welcome to apply! [PhD Openings][Postdoc Openings]...... Read More

November 16, 2021

November 16, 2021- Our paper is published on Cell Reports Medicine, reporting a step closer to making “off-the-shelf” immune cell...... Read More

August 5, 2021

May 11, 2021- Our off-the-shelf cell therapy technology is licensed by a Biotech startup, Appia Bio, for commercial development. The...... Read More

May 18, 2021

Dr. Lili Yang receives a $5.9 million CIRM Partnering Opportunity for Translational Research Projects Award to translate a new stem...... Read More