We are currently recruiting PhD students (2 openings) and postdoctoral researchers (1 opening). Welcome to apply! [PhD Openings][Postdoc Openings]... Read More
Our research centers on deciphering the cellular and molecular mechanisms controlling antitumor immunity, and exploiting knowledge to device the next-generation cancer immunotherapies.
Two active research directions are:
1.Identify new immune checkpoints and develop new immune checkpoint blockade therapy for cancer.
2. Develop novel “off-the-shelf” allogeneic immune cell therapies for cancer.
Lee D*, Dunn ZS*, Guo W*, Rosenthal CJ, Penn NE, Yu Y, Zhou K, Li Z, Ma F, Li M, Song T-C, Cen X, Li Y-R, Zhou JJ, Pellegrini M, Wang P, and Yang L. (*Co-first authors) Unlocking the potential of allogeneic Vδ2 T cells for ovarian cancer therapy through CD16 biomarker selection and CAR/IL-15 engineering. Nat Commun. 2023, 14(1):6942. doi: 10.1038/s41467-023-42619-2. [Nature Communications PDF][UCLA News PDF][Springer Nature Blog PDF]
Li Y-R*, Dunn ZS*, Yu Y, Li M, Wang P#, and Yang L#.(*Co-first authors; #Co-corresponding authors) Advancing cell-based cancer immunotherapy through stem cell engineering. Cell Stem Cell. 2023, 30(5):592-610. [Cell Stem Cell PDF]
Li Y-R*, Zhou Y*, Kim Y, Zhu Y, Ma F, Yu J, Wang Y-C, Chen X, Li Z, Zeng S, Wang X, Lee D, Ku J, Tsao T, Hardoy C, Huang J, Cheng D, Montel-Hagen A, Seet CS, Crooks GM, Larson SM, Sasine JP, Wang X, Pellegrini M, Ribas A, Kohn DB, Witte O, Wang P, and Yang L. (*Co-first authors). Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy. Cell Rep Med. 2021, 2(11):100449. [Cell Reports Medicine PDF][UCLA News PDF][BSCRC News PDF][JCCC News PDF][Life Sciences News PDF][Science Daily PDF][CIRM Blog PDF]
Wang X, Li B, Kim Y, Wang Y, Li Z, Yu J, Zeng S, Ma X, Choi I, Di Biase S, Smith DJ, Zhou Y, Li Y, Ma F, Huang J, Clarke N, To A, Gong L, Pham A, Moon H, Pellegrini M, and Yang L. Targeting monoamine oxidase A for T cell-based cancer immunotherapy. Sci Immunol. 2021, 6:eabh2383. [Science Immunology PDF][Science Magazine News PDF][UCLA News PDF][CBS News PDF][NBC News PDF][Fierce Biotech News PDF][Drug Target Review News PDF]
We are currently recruiting PhD students (2 openings) and postdoctoral researchers (1 opening). Welcome to apply! [PhD Openings][Postdoc Openings]... Read More
November 15, 2023- Dr. Lili Yang’s talk at the 38th SITC Annual Meeting is featured in ACIR (Accelerating Cancer Immunotherapy... Read More
March 7, 2023- Dr. Lili Yang is named on the BIOS list of Top Women in Academic Entrepreneurship alongside recent... Read More
May 11, 2021- Our off-the-shelf cell therapy technology is licensed by a Biotech startup, Appia Bio, for commercial development. The... Read More
Dr. Lili Yang receives a $5.9 million CIRM Partnering Opportunity for Translational Research Projects Award to translate a new stem... Read More